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New Research - January 2010
Ciclesonide versus Fluticasone: Effect on Small Airways in Mild Persistent Asthma
Summary
This study evaluated 30 patients with mild persistent asthma. They were randomized to receive either 100 mcg of fluticasone propionate b.i.d. or 200 mcg of ciclesonide daily for eight weeks. Impulse oscillometry and sputum eosinophilia was assessed.
Ciclesonide improved impulse oscillometry findings greater than fluticasone for the following measurements:
Small airway resistance p<0.05.
Distal reactants p<0.01.
Reactants area p<0.01.
In addition, there was a decrease in late phase sputum eosinophil level in the ciclesonide treated group compared to the fluticasone treated group (p<0.01).
However, routine spirometry showed no differences between the two groups.
The authors concluded that ciclesonide was superior to fluticasone in improving small airways function as measured by impulse oscillometry and also more effective in diminishing airway inflammation as measured by sputum eosinophilia. The authors pointed out that these findings were noted in spite of the fact that no differences could be detected between the two treated groups by routine spirometry.
Reference
Hoshino M. Comparison of effectiveness in ciclesonide and fluticasone propionate on small airway function in mild asthma. Allergology International 2010 (January); available online.
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